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Under the action of DMT1, Fe 3+ is converted to Fe 2+

These results also indicate a change in the expression of synaptic dopamine receptor proteins (D1 and D2), a decreased in serotonergic receptors (5-HT1A and 5-HT2A), metabotropic GABA-B, and muscarinic receptors (18)

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Recently, exhaustion of GSH in cisplatin-resistant cells has been extensively utilized to strengthen the cytotoxicity of cisplatin and sensitize chemotherapy ( Platinum precursors such as Pt () are applied to produce Pt () as a GSH-scavenging agent